Medical Research
Innovative Solutions For Omics Research Based On Omics AI
Well-healthcare has always insisted on building a mass spectrometry product and service system with micro-nano-materials technology (MT), high-throughput bio-detection technology (BT) and informatics technology (IT) as the underlying technological architecture, the core of which is the highly efficient extraction of non-targeted histology molecules, the acquisition and effective preprocessing of mass spectrometry signals, and the establishment of models and databases. We have developed micro-nano mass spectrometry chips with high efficiency laser energy absorption and charge transfer capabilities, which realize high-throughput detection of metabolic molecules and lipid molecules as well as molecular imaging. We have also developed a series of quality control systems including quality control products, calibration products, and quality control software, which enable a high degree of correspondence and reproducibility of data from different batches of research. Omics AI, a new histology research technology platform established by Well-healthcare using IVD technology system, will rapidly promote the application of basic histology research.
95% of Well-healthcare's medical cooperation team has doctoral and master's degrees from 985 universities, specializing in basic medicine, molecular and cellular biology, genetics, materials science and bioinformatics, etc. They have been working in the field of medical research for many years, and have experience in managing the full cycle of more than 200 projects from the National Natural Science Foundation of China (NSFC), national major scientific and technological special projects, key R&D programs of provincial science and technology departments, as well as provincial major scientific and technological programs for medicine and health care. He has experience in managing the full cycle of more than 200 projects under the National Natural Science Foundation of China, National Major Science and Technology Projects, Provincial Science and Technology Department's Key R&D Programs, and Provincial Major Science and Technology Programs for Medicine and Health.
Same-platform translation from drug target/diagnostic biomarker discovery to clinical application
Innovative Technology Platforms
Clinical Scenarios
Research and Transformation Results
Basic Scientific Research
Clinical Center
Industry-University-Research Cooperation
Industrialization Transformation
Omics Testing
High-throughput small molecule metabolomic assays
Quick Discovery（Metabolomics）
This platform can enrich and capture the metabolic small molecule population (molecular weight below 400 Da) in samples with high throughput and high stability, and examine the changes of small molecule metabolites in multivariate clinical samples (serum/plasma, urine, saliva, atrial fluid, cerebrospinal fluid, cells, tissues, etc.). It can be applied to research scenarios such as disease marker screening, molecular typing, drug sensitivity prediction and efficacy monitoring.
Highly sensitive detection of specific lipid groups
Specific Lipids Panel
High-throughput, high-coverage lipidomic assays
Global Discovery (Lipidomics)
Lipids, as important structural components and energy storage substances in living organisms, are involved in a variety of physiological processes such as regulating cell signaling and maintaining cell function. Therefore, the study of lipidomics is of great significance for understanding the mechanism of disease, early diagnosis and treatment. This platform can provide a new strategy for the detection of non-targeted lipidomes and specific lipidomes with high throughput, high coverage, and high sensitivity to specific lipids.
Spatial metabolome assay
Multi-D vision (Metabolomics)
Spatial metabolomics makes up for the lack of information on the spatial distribution of metabolites/lipids in biological tissues in traditional small molecule metabolomics/lipidomics studies. Huijian's original Multi-D vision-Metabolomics technology has the technical advantages of matrix-free, highly sensitive and stable imaging, which extends the metabolomics/lipidomics information to the three-dimensional level. Applicable fields include, but are not limited to, biomarker mining and pathway analysis, tumor margin identification, tumor benign and malignant discrimination and typing, and spatial multi-omics research.
High-throughput Endogenous Peptidomics
Endogenous peptides are involved in physiological and pathological processes through transcriptional regulation, post-transcriptional regulation, protein-protein interactions, enzyme activity, signaling, and intercellular communication. At the same time, endogenous peptides are considered to be one of the most ideal liquid biopsy markers because of their small molecular weight, close relationship with disease, and easy to cross the barrier into body fluids. The high-throughput endogenous peptide group research solution can capture and enrich peptides through Bio-pSi® micro-nano particle materials and detect them in combination with mass spectrometry platform detection, which can realize the detection of peptides in micro-samples with high throughput, high stability, high sensitivity and wide coverage, laying the foundation for basic research and clinical transformation of peptide groups.
High-throughput 4D Proteomics
As the core driving force of post-genomic era and precision medicine, proteomics provides an inexhaustible driving force for the development of life science and basic medicine.
The high-throughput 4D-proteome research solution uses micro and nano particles to capture and enrich the peptides after enzymolysis, and then detects them on mass spectrometry platforms such as Bruker timsTOF HT and Orbitrap, which can simultaneously ensure ultra-high sensitivity and high throughput detection, and achieve wider dynamic range, deeper coverage and more accurate quantitative analysis of proteins. It is helpful for the research of routine quantitative proteomics, modified proteomics, spatial proteomics and precision medicine.
High-throughput Glycomics
Glycosylation is a kind of extensive post-translational modification of proteins. It affects the spatial conformation, activity, stability, localization and function of proteins, and is involved in cell recognition, cell adhesion, signal transduction, receptor activation and immune response. It is related to various physiological and pathological processes. Well-healthcare Technologies has established a high-throughput glycoomics research solution based on advanced micro and nano materials and mass spectrometry platform, which enables the accurate detection and identification of sugar chains in small samples, and reveals the influence of glycoproteins and potential regulatory mechanisms.
Nanointegrative genomics research
Nano Integrated Discovery (Multiomics)
This platform can not only simultaneously detect small molecules of metabolome, lipidome, proteins and peptides, and nucleic acid molecules, but can also be combined with genomic, transcriptomic, microbiomic, and imaging data acquired by non-mass spectrometry platforms to build a multimodal data integration and analysis model, which is becoming a broadly applicable strategy for the comprehensive study of organisms and diseases.
Medical Research Services
Well-healthcare Medical Research Services is a high value-added service introduced by the Huijian Medical Partnering Team that differentiates itself from the above platform business. It can be based on the Omics-AI technology platform under Huijian's IVD-grade quality control system, and provides exclusive medical research tools and services to clinical research teams in specific areas of researcher's focus. Helping your team to choose highly effective and disruptive research in the right emerging areas in order to secure sustained research funding and provide the best chance of realizing important research breakthroughs in today's highly competitive research environment. Thus, strengthening your organization's ability to innovate and research ahead of competitors in cutting-edge medical research areas where research size and complexity are growing.
1Medical Research Services Content
2IVD Level Quality Control System
The scientific research services provided by Welkin are based on an IVD-level quality control system, which complies with standards and relevant technical specifications including ISO13485 quality management system. Quality control measures are carried out throughout the entire process of raw material control, production process control, quality testing and validation, batch record management, sample management and tracking, standardized testing, etc., and therefore the accuracy, reproducibility and stability of the experimental data and results are greatly guaranteed. Therefore, the accuracy, reproducibility and stability of experimental data can be greatly guaranteed, which is the biggest advantage of our company compared with other scientific research companies.
Cooperation achievements
Fourteenth Five-Year National Key Research and Development Program1
Provincial Key R&D Program6(Pointman, Leader of the Geese)
Participation in the application for the National Natural Fund was approved>50
Provincial-Ministerial Joint Construction of Major Programs3
High level SCI papers>100
Nearly 30 articles in ACS Nano, Adv Funct Mater, Angew Chem Int Ed Engl, Theranostics, ACS Appl Mater Interfaces, Adv Healthc Mater, and other journals of 10th grade and above.
